Tesofensine: Research Profile, Dosages & Supplier Prices

Metabolic research (small molecule) · Powder (oral small molecule) · Also known as: NS2330, triple monoamine reuptake inhibitor

Tesofensine is a metabolic research (small molecule) compound with a molecular weight of 328.3 g/mol and a research half-life of ~8-9 days (very long). Tesofensine is a triple monoamine reuptake inhibitor - blocking serotonin, norepinephrine and dopamine reuptake - originally developed for Parkinson's and Alzheimer's disease. During those trials researchers noticed substantial, dose-dependent weight loss, and development pivoted to obesity, where Phase 2 data showed weight loss roughly double that of then-available medications.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Non-peptide small molecule
Formula	C17H23Cl2NO
Mol. weight	328.3 g/mol
Half-life	~8-9 days (very long)
Forms sold	Powder (oral small molecule)

What is Tesofensine?

Its weight-loss effect comes from combined appetite suppression and increased energy expenditure and fat oxidation, driven by the triple neurotransmitter action. Though not a peptide, it is a staple of metabolic research catalogs and is frequently studied alongside GLP-1 agonists as a mechanistically distinct (central monoaminergic vs incretin) approach. The very long half-life of over a week is a defining pharmacokinetic feature.

Mechanism of Action (Research Context)

Triple reuptake inhibitor of serotonin, norepinephrine and dopamine transporters (SERT/NET/DAT). Central appetite suppression plus increased thermogenesis and fat oxidation; dopaminergic action modulates food reward pathways.

Research Areas

Obesity and appetite regulationMonoamine transporter pharmacologyEnergy expenditure / thermogenesisFood reward signaling

Tesofensine Dosages in Research

0.25mg0.5mg1mg (trial reference doses)

Phase 2 obesity trials used 0.25-1 mg once daily. Microgram-to-milligram compound with ~8-9 day half-life. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Powder: room temperature desiccated or 2-8C, protected from light. Stable small molecule.

Tesofensine Supplier Price Comparison

No tracked suppliers stock Tesofensine yet — inventory syncs run continuously. Check our supplier reviews.

Tesofensine FAQ

No - it is a small-molecule triple monoamine reuptake inhibitor. It appears in metabolic research catalogs because it is studied for the same obesity research questions as GLP-1 peptides.

Obesity primarily: Phase 2 trials showed roughly double the weight loss of older medications. Mechanistically it combines appetite suppression with increased energy expenditure via serotonin, norepinephrine and dopamine reuptake blockade.

98%+ HPLC purity and mass spec identity at 328.3 Da. Note the long half-life means steady-state accumulation matters in study design.

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