ACE-031: Research Profile, Dosages & Supplier Prices
ACE-031 is a growth factor research compound with a molecular weight of ~90-100 kDa (dimer) and a research half-life of ~10-14 days (fc-fusion). ACE-031 is a recombinant fusion protein combining the extracellular domain of the activin receptor type IIB (ActRIIB) with the Fc region of human IgG1. It acts as a soluble decoy receptor, capturing myostatin, activins and other TGF-beta ligands before they can signal through cell-surface receptors. It was developed by Acceleron Pharma and reached Phase 2 trials in Duchenne muscular dystrophy before development was halted.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | Recombinant fusion: extracellular domain of human ActRIIB linked to human IgG1 Fc |
| Formula | Protein fusion construct |
| Mol. weight | ~90-100 kDa (dimer) |
| Half-life | ~10-14 days (Fc-fusion) |
| Forms sold | Lyophilized powder |
What is ACE-031?
In clinical research ACE-031 produced clear increases in lean body mass and thigh muscle volume after a single dose, validating the ligand-trap approach to myostatin pathway inhibition. The Fc fusion gives it an antibody-like half-life of around two weeks - completely unlike short-lived peptides. It remains an important reference compound in muscle-wasting research, and its trial data is frequently cited when evaluating newer ActRIIB pathway agents such as bimagrumab.
Mechanism of Action (Research Context)
Soluble ligand trap: the ActRIIB extracellular domain binds myostatin (GDF-8), activins A/B and GDF-11 with high affinity, preventing ActRIIB/ALK4-5 receptor activation and SMAD2/3 signaling. The IgG1 Fc domain confers extended circulation via FcRn recycling.
Research Areas
ACE-031 Dosages in Research
Clinical trials dosed 0.02-3 mg/kg subcutaneously with effects lasting weeks. Research-context only; development was discontinued after Phase 2.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Lyophilized: -20C or colder. Reconstituted: 2-8C, use within days; Fc-fusion proteins are aggregation-prone - handle gently, avoid freeze-thaw.
ACE-031 Supplier Price Comparison
| Supplier | Product | Price | Score |
|---|---|---|---|
| Peptides, Steroid Powders & Biochemical Raw Materials | ACE-031 5mg Peptide – Myostatin Inhibitor for Research Use | ACDC 5mg | — | ★ 1.8 |
| Buy Nouveaux Ltd Pharma Steroid Online | ACVR2B (ACE-031) | — | ★ 1.8 |
| Nutritionis Ingredientia, Formulae nutritionis & curis OEM&ODM Manufacturer, Supple | ACE-031 Peptide | — | ★ 2.2 |
| Wholesale high | ACE-031 (CAS 1621169-52-5) High purity peptide Factory manufactured | $42.00 | ★ 2.6 |
| CamoChem | ACE-031 EU | $43.75 | ★ 2.9 |
| 24Peptides | ACE-031 1mg 1mg | $54.00 | ★ 2.2 |
| BD Peptides | ACE-031 1mg 1mg | $59.99 | ★ 1.4 |
| Verified Wholesale Peptides | ACE-031 (Myostatin Inhibitor) | 1mg x 10 Vials Kit | >99% Purity 1mg | $59.99 | ★ 2.0 |
| Home | ACE-031 | $79.99 | ★ 2.5 |
| 808 Peptides LLC | ACE-031 (1mg) 1mg | $120.00 | ★ 1.9 |
| Apex Peptides | ACE 031 1mg 1mg | $140.00 | ★ 2.3 |
| American Peptide Innovations | ACE-031 (1mg) 1mg | $140.00 | ★ 1.9 |
| Research Peptides in the USA | ACE-031 Peptide | $145.00 | ★ 2.1 |
| Apex DNA Peptides | ACE-031 (1mg) 1mg | $150.00 | ★ 1.9 |
| Home | Core Peptides ACE-031 – 1MG 1MG | $173.00 | ★ 2.3 |
| Alpha Amino Labs | ACE-031 (1mg) 1mg | $180.00 | ★ 1.9 |
| Research Peptides, Third | ACE-031 (1mg) 1mg | $180.00 | ★ 2.1 |
| Apex Health Performance | ACE-031 (1mg) 1mg | $180.00 | ★ 2.0 |
| Apex Gains LLC | ACE-031 Peptide | $185.00 | ★ 2.1 |
| American Select Peptides – Research peptides and analytical standards for qualified laboratories. | ACE-031 | $209.00 | ★ 1.7 |