Argireline: Research Profile, Dosages & Supplier Prices

Cosmetic / tissue research · Lyophilized powder · Also known as: Acetyl Hexapeptide-3, Acetyl Hexapeptide-8, Ac-EEMQRR-NH2

Argireline is a cosmetic / tissue research compound with a molecular weight of 889.0 g/mol and a research half-life of topical/local research use. Argireline (acetyl hexapeptide-8) is a synthetic hexapeptide patterned after the N-terminal end of SNAP-25, one of the three proteins forming the SNARE complex that drives neurotransmitter release at neuromuscular junctions. It was designed as a topical, non-invasive functional analog of botulinum toxin's mechanism - destabilizing SNARE complex assembly to soften facial muscle contraction.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Formula	C34H60N14O12S
Mol. weight	889.0 g/mol
Half-life	Topical/local research use
Forms sold	Lyophilized powder

What is Argireline?

It became the most famous 'cosmetic peptide' in the world, anchoring an entire category of expression-line research. In-vitro and clinical cosmetic studies report reduced wrinkle depth with topical application, and it remains the benchmark against which newer neurocosmetic peptides (SNAP-8, leuphasyl) are compared. In research catalogs it serves as a SNARE-complex tool compound as much as a cosmetic ingredient.

Mechanism of Action (Research Context)

SNAP-25 mimetic: competes with native SNAP-25 for incorporation into the SNARE complex, destabilizing vesicle fusion and reducing acetylcholine release at the neuromuscular junction - a milder, reversible echo of botulinum toxin's proteolytic mechanism.

Research Areas

SNARE complex biologyExpression-line / wrinkle modelsTopical peptide deliveryNeuromuscular signaling research

Argireline Dosages in Research

100mg1g (cosmetic formulation research)

Cosmetic research formulations typically use 2-10% solutions applied topically. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated. Reconstituted or in formulation: 2-8C, protected from light; use within weeks.

Argireline Supplier Price Comparison

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Argireline FAQ

Both target the SNARE complex: botulinum toxin cleaves SNAP-25 enzymatically, while Argireline is a SNAP-25 fragment that competitively destabilizes SNARE assembly - a much milder, reversible effect studied for topical use.

Expression-line reduction in cosmetic research, SNARE-complex pharmacology, and topical peptide delivery. It is the benchmark neurocosmetic peptide.

98%+ HPLC purity and mass spec identity at 889.0 Da. Note acetyl hexapeptide-3 and -8 are the same molecule under different INCI names.

Age & Use Verification