AICAR: Research Profile, Dosages & Supplier Prices
AICAR is a metabolic research (small molecule) compound with a molecular weight of 258.2 g/mol and a research half-life of short (rapid cellular uptake and phosphorylation). AICAR (acadesine) is an adenosine analog and the prototypical pharmacological activator of AMPK - the cell's central energy-sensing kinase. Inside cells it is phosphorylated to ZMP, an AMP mimetic that allosterically activates AMPK, switching cells from energy storage to energy production: increased glucose uptake, fatty acid oxidation and mitochondrial biogenesis.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | Non-peptide small molecule (adenosine analog) |
| Formula | C9H14N4O5 |
| Mol. weight | 258.2 g/mol |
| Half-life | Short (rapid cellular uptake and phosphorylation) |
| Forms sold | Lyophilized powder |
What is AICAR?
It became famous in 2008 when a landmark study showed it enhanced endurance in sedentary mice - the original 'exercise in a pill' result - and it has been a WADA-prohibited substance ever since. Beyond exercise biology, AICAR (as acadesine) has genuine clinical history in cardiac surgery ischemia protection trials. In research it remains the standard positive-control AMPK activator used across metabolism, cancer and inflammation studies.
Mechanism of Action (Research Context)
Cell-permeable adenosine analog phosphorylated intracellularly to ZMP, which mimics AMP and allosterically activates AMP-activated protein kinase (AMPK). Downstream: increased GLUT4 translocation, fatty acid oxidation, and PGC-1alpha-driven mitochondrial biogenesis.
Research Areas
AICAR Dosages in Research
Rodent exercise/metabolism studies typically use 250-500 mg/kg; cell culture uses 0.5-2 mM. Research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Lyophilized: -20C desiccated. Reconstituted: 2-8C, use within 1-2 weeks or aliquot and freeze.
AICAR Supplier Price Comparison
| Supplier | Product | Price | Score |
|---|---|---|---|
| Leading Peptide Research Company | AICAR 50mg 50mg | — | ★ 2.2 |
| Peptides, Steroid Powders & Biochemical Raw Materials | AICAR (Acadesine) 50mg – In stock 50mg | — | ★ 1.8 |
| Login Redirect | AICAR | — | ★ 2.6 |
| Home | AICA Ribonucleotide (AICAR) 50mg 50mg | $25.00 | ★ 2.3 |
| Home | AICAR | $31.00 | ★ 2.0 |
| Amino USA: Premium & Third | AICAR 50mg 50mg | $45.00 | ★ 2.2 |
| AVGSciences – US Medicine | AICAR 50mg 50mg | $49.95 | ★ 3.2 |
| Apex Peptides | Aicar | $53.00 | ★ 2.3 |
| 24Peptides | AICAR 50mg 50mg | $54.00 | ★ 2.2 |
| AIO Peptides: Buy High | AICAR 50mg 50mg | $54.00 | ★ 2.0 |
| Buy Peptides for Laboratory Research | AICAR 50mg 50mg | $54.99 | ★ 2.8 |
| Home | AICAR | $55.00 | ★ 1.8 |
| American Peptide Innovations | AICAR (50mg) 50mg | $55.00 | ★ 1.9 |
| No. 1 Steroids Store 1pharmacologyusa.com | AICAR 50 mg ST Biotechnology 50mg | $58.50 | ★ 3.0 |
| Home | Core Peptides AICAR – 50MG 50MG | $62.00 | ★ 2.3 |
| My account – Axon | AXP-AICAR | $62.99 | ★ 2.1 |
| Ascend Peptides | AICAR | $64.99 | ★ 1.9 |
| Research Peptides for Sale – US | AICAR (1 Vial) | $69.99 | ★ 2.2 |
| Home | AICAR | $72.00 | ★ 1.8 |
| American Select Peptides – Research peptides and analytical standards for qualified laboratories. | AICAR | $79.00 | ★ 1.7 |
| Wholesale high | AICAR Peptide 99% High Purity Wholesale (50mg / 100mg) 50mg / 100mg | $86.00 | ★ 2.6 |
| Research Peptides — Third | AICAR (50mg) 50mg | $87.99 | ★ 1.9 |
| Apex Gains LLC | Aicar Peptide | $100.00 | ★ 2.1 |
| Apex Health Performance | AICAR (50mg) 50mg | $130.00 | ★ 2.0 |
| Apex DNA Peptides | AICAR (50mg) 50mg | $130.00 | ★ 1.9 |
| Alpha Amino Labs | AICAR(50 mg) 50mg | $130.00 | ★ 1.9 |
| Buy Peptides UK | AICAR (10 pack) | $258.75 | ★ 2.3 |
| Evolve Anti | AICAR | $285.00 | ★ 2.5 |
| GHBKoshop | AICAR Peptide 99% Pure | CAS 2627-69-2 | 10 Vials/Box – Pharma Grade | $290.00 | ★ 2.6 |
| Home | AICAR (50mg) (10 Vials) 50mg | $400.99 | ★ 2.3 |