Ac-SDKP: Research Profile, Dosages & Supplier Prices
Ac-SDKP is a anti-fibrotic research compound with a molecular weight of 487.5 g/mol and a research half-life of ~4-5 minutes (cleaved by ace). Ac-SDKP is a naturally occurring tetrapeptide released from thymosin beta-4 by prolyl oligopeptidase, and destroyed within minutes by angiotensin-converting enzyme (ACE). Despite its fleeting half-life it is a significant endogenous regulator: a hematopoietic stem cell inhibitor and, more prominently in current research, an anti-fibrotic and anti-inflammatory signal in heart, kidney and lung tissue.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | Ac-Ser-Asp-Lys-Pro-OH |
| Formula | C20H33N5O9 |
| Mol. weight | 487.5 g/mol |
| Half-life | ~4-5 minutes (cleaved by ACE) |
| Forms sold | Lyophilized powder |
What is Ac-SDKP?
Research interest surged with the recognition that part of the organ-protective benefit of ACE inhibitors may come from raising Ac-SDKP levels - blocking its breakdown. Animal studies show Ac-SDKP reduces cardiac and renal fibrosis, macrophage infiltration and TGF-beta signaling. It is also the C-terminal cleavage product released from TB-500's parent molecule, linking it to the broader thymosin beta-4 research story.
Mechanism of Action (Research Context)
Anti-fibrotic signaling: suppresses TGF-beta/Smad-driven collagen deposition, inhibits macrophage and myofibroblast activation, and inhibits hematopoietic stem cell proliferation via cell-cycle arrest. Rapidly inactivated by ACE N-domain cleavage.
Research Areas
Ac-SDKP Dosages in Research
Animal fibrosis studies typically use continuous infusion (osmotic minipumps) because of the ~4-minute half-life. Research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Lyophilized: -20C desiccated. Reconstituted: 2-8C, use promptly; short plasma half-life reflects enzymatic rather than solution instability.
Ac-SDKP Supplier Price Comparison
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