Melanotan I: Research Profile, Dosages & Supplier Prices
Melanotan I is a melanocortin research compound with a molecular weight of 1646.8 g/mol and a research half-life of ~1-2 hours (injectable); sustained release with implant forms. Melanotan I (afamelanotide) is a synthetic linear tridecapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH), developed as a more receptor-selective alternative to Melanotan II. It primarily activates the melanocortin-1 receptor (MC1R) on melanocytes, stimulating eumelanin production - the dark brown/black pigment associated with photoprotection.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Formula | C78H111N21O19 |
| Mol. weight | 1646.8 g/mol |
| Half-life | ~1-2 hours (injectable); sustained release with implant forms |
| Forms sold | Lyophilized powder |
What is Melanotan I?
Afamelanotide is one of the few research peptides to reach full regulatory approval in a pharmaceutical context: as a subcutaneous implant (Scenesse) it is approved in the EU and US for preventing phototoxicity in adults with erythropoietic protoporphyria (EPP). In research settings it is studied for UV-damage models, melanogenesis pathways, and MC1R signaling. Compared with Melanotan II it shows far less activity at MC3R/MC4R, which is why it is considered the more selective - and milder - melanocortin tool compound.
Mechanism of Action (Research Context)
Selective agonist at the melanocortin-1 receptor (MC1R), mimicking alpha-MSH. MC1R activation raises intracellular cAMP in melanocytes, upregulating tyrosinase activity and shifting pigment synthesis toward eumelanin. Minimal agonism at MC3R/MC4R distinguishes it from non-selective melanocortins.
Research Areas
Melanotan I Dosages in Research
Published human research with afamelanotide used 16mg subcutaneous implants releasing drug over days. In vitro and animal melanogenesis studies typically work in microgram ranges. All dosing information is research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Store lyophilized at -20C protected from light. After reconstitution refrigerate at 2-8C and use within 2-4 weeks; avoid repeated freeze-thaw cycles.
Melanotan I Supplier Price Comparison
| Supplier | Product | Price | Score |
|---|---|---|---|
| Moddo Labs – Discovering the Future of Research | Melanotan 1 | — | ★ 1.4 |
| Home | MT-1 (Melanotan I) | — | ★ 2.8 |
| Pure Peptides UK | Melanotan 1 | $22.00 | ★ 2.7 |
| Home | Melanotan I 10mg 10mg | $22.00 | ★ 2.0 |
| Schöne, langanhaltende und gleichmäÃige bräune | Melanotan 1 – Nasal – Spray – 20mg 20mg | $23.00 | ★ 1.6 |
| Schöne, langanhaltende und gleichmäÃige bräune | Melanotan 1 – 10mg 10mg | $23.00 | ★ 1.6 |
| AIO Peptides: Buy High | Melanotan I 10mg 10mg | $24.00 | ★ 2.0 |
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| Natty Lab Co · Research Materials, Done Right | MT-1 10MG 10mg | $25.00 | ★ 1.9 |
| Pure Peptides UK | Melanotan 1 Nasal Spray Kit | $28.99 | ★ 2.7 |
| Atomik Labs Peptides: Buy High | Melanotan I – 10mg (Current batch tested at 12mg) 10mg | $29.00 | ★ 2.3 |
| Amino Club | Melanotan I Research Peptide – 10MG 10MG | $29.99 | ★ 1.6 |
| Buy Peptides Online USA | Melanotan I Research Peptide – 10MG 10MG | $29.99 | ★ 1.6 |
| Home | Melanotan I 10mg 10mg | $30.00 | ★ 2.9 |
| Home | Melanotan 1 | $31.00 | ★ 2.0 |
| One moment, please... | Melanotan I 10MG 10mg | $32.00 | ★ 1.5 |
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| Buy Amino Peptides | Melanotan I 10mg 10mg | $35.00 | ★ 1.9 |
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| Alpha Omega Peptides | Melanotan I (MT-1) 10MG 10MG | $37.00 | ★ 2.3 |
| Adria Science | Melanotan-1 | $39.90 | ★ 1.8 |
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| One moment, please... | MT-1 (Melanotan I) | $40.00 | ★ 1.6 |
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| Research Peptides USA | Melanotan 1 10mg 10mg | $40.00 | ★ 2.7 |
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| Schöne, langanhaltende und gleichmäÃige bräune | Melanotan 1 – 20mg 20mg | $41.00 | ★ 1.6 |
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