VIP: Research Profile, Dosages & Supplier Prices
VIP is a neuropeptide research compound with a molecular weight of 3325.8 g/mol and a research half-life of ~1-2 minutes (plasma); longer inhaled. VIP (vasoactive intestinal peptide) is a 28-amino-acid neuropeptide of the secretin/glucagon family, originally isolated from intestine but now known to be widely distributed through the nervous, immune, cardiovascular and pulmonary systems. It is a potent vasodilator, bronchodilator and immunomodulator with an unusually broad physiological footprint.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
| Formula | C147H238N44O42S |
| Mol. weight | 3325.8 g/mol |
| Half-life | ~1-2 minutes (plasma); longer inhaled |
| Forms sold | Lyophilized powder |
What is VIP?
A synthetic form (aviptadil) has been investigated clinically for pulmonary hypertension, ARDS, sarcoidosis and critical COVID-19, typically by inhalation to exploit its short plasma half-life. In research, VIP is a key tool for studying VPAC1/VPAC2 receptor signaling, circadian rhythm regulation in the suprachiasmatic nucleus, and immune tolerance - it shifts immune responses toward anti-inflammatory Th2/Treg profiles. Its extreme plasma instability (half-life of about a minute) is the central experimental challenge.
Mechanism of Action (Research Context)
Agonist at VPAC1 and VPAC2 Gs-coupled receptors, raising cAMP. Produces vasodilation, bronchodilation, increased secretion, and immunomodulation (suppressed Th1 responses, induced regulatory T cells). Degraded rapidly by neutral endopeptidases.
Research Areas
VIP Dosages in Research
Clinical aviptadil research used inhaled or IV dosing in microgram ranges given the ~1-minute plasma half-life. Research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Lyophilized: -20C desiccated. Reconstituted: 2-8C and use quickly - among the least stable catalog peptides in solution; aliquot and freeze at -80C for longer storage.
VIP Supplier Price Comparison
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