Thymulin: Research Profile, Dosages & Supplier Prices

Immune research · Lyophilized powder · Also known as: Facteur Thymique Serique (FTS), Serum Thymic Factor

Thymulin is a immune research compound with a molecular weight of 858.9 g/mol and a research half-life of short (minutes-hours). Thymulin is a zinc-dependent nonapeptide hormone secreted by thymic epithelial cells, first isolated from porcine serum as 'facteur thymique serique'. Its biological activity is strictly dependent on binding zinc ions, which stabilize the active conformation - a distinctive feature among thymic peptides.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	pyroGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH (zinc-bound)
Formula	C33H54N12O15
Mol. weight	858.9 g/mol
Half-life	Short (minutes-hours)
Forms sold	Lyophilized powder

What is Thymulin?

Research interest in thymulin centers on T-cell differentiation and the neuroendocrine-immune axis. Circulating thymulin declines steeply with age in parallel with thymic involution, making it a marker - and candidate mediator - of immunosenescence. Studies have explored its roles in T-cell maturation, cytokine balance, pain and inflammation models, and even ovarian function. Because activity requires zinc coordination, research preparations must account for the metal-binding state.

Mechanism of Action (Research Context)

Zinc-bound nonapeptide acting on immature T-cell precursors to promote differentiation and modulate T-cell surface markers. Interfaces with the hypothalamic-pituitary axis; anti-inflammatory effects reported via reduced pro-inflammatory cytokine release in several models.

Research Areas

T-cell differentiation and thymic functionImmunosenescence / aging researchNeuroendocrine-immune interactionsInflammation and pain models

Thymulin Dosages in Research

5mg10mg vials

Animal studies use microgram-range dosing; zinc availability influences measured activity in assays. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated. Reconstituted: 2-8C, use within 2 weeks. Zinc-free buffers will render the peptide inactive in functional assays.

Thymulin Supplier Price Comparison

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Thymulin FAQ

Thymulin is only biologically active when coordinated to a zinc ion, which stabilizes its active conformation. The zinc-free peptide (FTS) is essentially inactive in functional assays.

T-cell maturation, age-related immune decline (immunosenescence), neuroendocrine-immune crosstalk, and anti-inflammatory effects in pain and inflammation models.

Both are thymic peptides involved in T-cell biology, but they are distinct molecules: thymulin is a 9-aa zinc-dependent peptide from thymic epithelium, while Thymosin Alpha-1 is a 28-aa peptide from the thymosin family.

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