Thymosin Beta-4: Research Profile, Dosages & Supplier Prices

Repair / recovery research · Lyophilized powder · Also known as: TB4, TMSB4X, full-length Thymosin Beta 4

Thymosin Beta-4 is a repair / recovery research compound with a molecular weight of 4963.5 g/mol and a research half-life of ~2-3 hours (plasma). Thymosin Beta-4 is a naturally occurring 43-amino-acid peptide found in virtually all human and animal cells, where it serves as the principal intracellular actin-sequestering protein. It is the parent molecule of the popular research fragment TB-500, which corresponds to the active LKKTETQ region of the full-length protein.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Formula	C212H350N56O78S
Mol. weight	4963.5 g/mol
Half-life	~2-3 hours (plasma)
Forms sold	Lyophilized powder

What is Thymosin Beta-4?

In preclinical research, Thymosin Beta-4 has been studied across wound healing, cardiac repair after infarction, corneal injury, and fibrosis models. Its biological roles include actin dynamics regulation, cell migration, angiogenesis promotion, and anti-inflammatory signaling. Because the full 43-aa chain is harder and more expensive to synthesize than the TB-500 fragment, it is less commonly stocked - and more commonly counterfeited - making third-party COAs especially important for this compound.

Mechanism of Action (Research Context)

Binds monomeric G-actin in a 1:1 complex, regulating actin polymerization and cytoskeletal dynamics. Promotes cell migration and differentiation, stimulates angiogenesis via VEGF-independent pathways, and modulates inflammatory cytokine release. The LKKTETQ motif (residues 17-23) is considered the primary bioactive region.

Research Areas

Wound healing and tissue repairCardiac repair post-infarction modelsCorneal injury and ocular surface researchAnti-fibrotic signalingActin cytoskeleton dynamics

Thymosin Beta-4 Dosages in Research

2mg5mg10mg vials

Animal wound-healing and cardiac studies have used a wide range of doses, typically micrograms per kilogram. Full-length TB4 is roughly 10x the molecular weight of the TB-500 fragment, so mass-equivalent dosing differs substantially. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C, desiccated, protected from light. Reconstituted: 2-8C, use within 2-3 weeks. The 43-aa chain is oxidation-sensitive at its methionine residue - avoid repeated freeze-thaw.

Thymosin Beta-4 Supplier Price Comparison

No tracked suppliers stock Thymosin Beta-4 yet — inventory syncs run continuously. Check our supplier reviews.

Thymosin Beta-4 FAQ

TB-500 is a short synthetic fragment containing the active LKKTETQ region of full-length Thymosin Beta-4 (43 amino acids). TB-500 is cheaper to synthesize and far more common; genuine full-length TB4 should show ~4963 Da on mass spec.

Demand a batch-specific third-party COA with mass spectrometry showing 4963.5 Da. Many vendors sell the TB-500 fragment mislabeled as full TB4 because the fragment is far cheaper to produce.

Preclinical research covers dermal wound healing, cardiac tissue repair after myocardial infarction, corneal repair, and anti-fibrotic effects. It remains a research-use-only compound outside clinical trials.

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