SS-31: Research Profile, Dosages & Supplier Prices

Mitochondrial research · Lyophilized powder · Also known as: Elamipretide, Bendavia, MTP-131

SS-31 is a mitochondrial research compound with a molecular weight of 639.8 g/mol and a research half-life of ~2-4 hours. SS-31 (elamipretide) is a synthetic tetrapeptide from the Szeto-Schiller series, engineered to selectively target the inner mitochondrial membrane. Its alternating aromatic-cationic motif lets it cross cell membranes freely and concentrate in mitochondria, where it binds cardiolipin - the signature phospholipid of the inner membrane that anchors the electron transport chain complexes.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	D-Arg-2',6'-dimethylTyr-Lys-Phe-NH2
Formula	C32H49N9O5
Mol. weight	639.8 g/mol
Half-life	~2-4 hours
Forms sold	Lyophilized powder

What is SS-31?

By stabilizing cardiolipin, SS-31 improves cristae architecture and electron transport efficiency while reducing electron leak and reactive oxygen species generation at the source. It has been through numerous clinical trials (as elamipretide/Bendavia) for mitochondrial myopathies, heart failure, and Barth syndrome, giving it one of the deepest clinical datasets of any research peptide. Preclinical research covers ischemia-reperfusion injury, neurodegeneration, muscle aging and kidney disease models.

Mechanism of Action (Research Context)

Selectively partitions into the inner mitochondrial membrane and binds cardiolipin, stabilizing cristae curvature and respiratory supercomplex organization. Reduces electron leak and mitochondrial ROS production, improves ATP synthesis efficiency, and inhibits cardiolipin peroxidation-driven cytochrome c release.

Research Areas

Mitochondrial dysfunction and bioenergeticsIschemia-reperfusion injuryHeart failure modelsNeurodegeneration researchSarcopenia and muscle aging

SS-31 Dosages in Research

10mg50mg vials

Clinical trials used intravenous and subcutaneous dosing in the milligram-per-day range; animal studies typically use 1-5 mg/kg. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated, protected from light. Reconstituted: 2-8C, use within 2-3 weeks.

SS-31 Supplier Price Comparison

No tracked suppliers stock SS-31 yet — inventory syncs run continuously. Check our supplier reviews.

SS-31 FAQ

Rather than scavenging ROS after they form, SS-31 binds cardiolipin in the inner mitochondrial membrane and reduces ROS generation at the electron transport chain source, while improving ATP production efficiency.

Yes - as elamipretide it has completed multiple Phase 2/3 trials in primary mitochondrial myopathy, heart failure and Barth syndrome, making it one of the most clinically studied research peptides.

98%+ HPLC purity and mass spec identity at 639.8 Da. Note the sequence contains D-arginine and dimethyltyrosine - non-standard residues that cheap synthesis can get wrong.

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