Somatropin: Research Profile, Dosages & Supplier Prices

Growth hormone research · Lyophilized powder · Also known as: Recombinant human growth hormone, rhGH, HGH, somatotropin (191aa)

Somatropin is a growth hormone research compound with a molecular weight of 22124 g/mol (22.1 kDa) and a research half-life of ~20-30 minutes (iv); 2-4 hours (subcutaneous). Somatropin is recombinant human growth hormone - a 191-amino-acid, 22 kDa protein identical to the predominant form secreted by the pituitary. It is the reference compound for the entire growth-hormone research field: the secretagogue peptides (sermorelin, tesamorelin, ipamorelin, the GHRPs) are all studied for their ability to make the body release this molecule.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	191-aa single-chain protein with two disulfide bridges (identical to endogenous pituitary GH)
Formula	C990H1528N262O300S7
Mol. weight	22124 g/mol (22.1 kDa)
Half-life	~20-30 minutes (IV); 2-4 hours (subcutaneous)
Forms sold	Lyophilized powder

What is Somatropin?

GH acts both directly and through hepatic and local IGF-1 production, regulating growth, body composition, protein metabolism and tissue repair. Pharmaceutical somatropin is an approved drug for growth hormone deficiency and related conditions; research-grade material is used in metabolism, aging, and muscle-wasting models. As a large protein requiring correct disulfide folding, it is produced only by recombinant expression - 'synthetic HGH' claims are a red flag, and 192-aa (somatrem) or truncated variants are inferior or counterfeit material.

Mechanism of Action (Research Context)

Dimerizes the growth hormone receptor (GHR), activating JAK2/STAT5 signaling. Direct effects include lipolysis and antagonism of insulin action; indirect effects are mediated by IGF-1 produced in liver and target tissues, driving growth, protein synthesis and cell proliferation.

Research Areas

Growth hormone axis physiologyIGF-1 mediated growth signalingBody composition and metabolism modelsMuscle wasting and aging research

Somatropin Dosages in Research

10 IU vials~3.3 mg per 10 IU

Dosed in IU (1 mg ~ 3 IU). Clinical research uses 0.1-0.3 mg/kg/week ranges divided into daily doses. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: 2-8C (do not freeze). Reconstituted: 2-8C, use within 2-3 weeks; highly aggregation-sensitive - never shake, swirl gently.

Somatropin Supplier Price Comparison

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Somatropin FAQ

It is a 191-amino-acid protein - technically a very large polypeptide. It anchors the GH category in research catalogs because secretagogue peptides are studied for stimulating its release.

Somatropin (191aa) is identical to natural human GH. The 192-aa variant (somatrem) has an extra methionine and is more immunogenic - it is considered inferior and its presence suggests outdated or low-quality manufacturing.

HPLC purity plus mass spec at 22124 Da, and ideally a bioactivity assay. Genuine rhGH is recombinant - any 'synthetic' or suspiciously cheap HGH should be treated as counterfeit.

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