PEG-MGF: Research Profile, Dosages & Supplier Prices

Growth factor research · Lyophilized powder · Also known as: PEGylated Mechano Growth Factor, PEG-MGF, IGF-1Ec (PEGylated)

PEG-MGF is a growth factor research compound with a molecular weight of ~2948 g/mol (peptide core, excluding PEG) and a research half-life of days (pegylation extends from minutes to ~48-72h). PEG-MGF is the polyethylene glycol-conjugated form of Mechano Growth Factor, the IGF-1Ec splice variant expressed in mechanically loaded or damaged muscle tissue. The 24-amino-acid MGF core is derived from the unique E-domain of IGF-1Ec and is studied for its role in activating muscle satellite cells independently of the IGF-1 receptor pathway used by mature IGF-1.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	PEG-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys
Formula	~C121H200N42O39 + PEG
Mol. weight	~2948 g/mol (peptide core, excluding PEG)
Half-life	Days (PEGylation extends from minutes to ~48-72h)
Forms sold	Lyophilized powder

What is PEG-MGF?

Native MGF has an extremely short half-life of only minutes, which limits experimental utility. PEGylation - covalent attachment of a polyethylene glycol chain - shields the peptide from proteolysis and renal clearance, extending its research half-life to several days. Preclinical studies have examined PEG-MGF in models of muscle injury, cardiac repair after ischemia, and neuroprotection. Because PEGylation chemistry varies between suppliers, mass-spec confirmation of the conjugate is a key quality check.

Mechanism of Action (Research Context)

The MGF E-domain peptide acts through an IGF-1R-independent pathway (putatively via a distinct receptor) to promote satellite cell activation and proliferation while suppressing premature differentiation. PEGylation does not change receptor pharmacology but dramatically reduces proteolytic degradation and renal clearance.

Research Areas

Muscle satellite cell biologyMechanical load / muscle damage modelsCardiac ischemia repairNeuroprotection models

PEG-MGF Dosages in Research

2mg5mg vials

Animal studies have used microgram-per-kilogram doses given the extended half-life; far less frequent administration than native MGF. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated and protected from light. Reconstituted: 2-8C, use within 2-3 weeks. PEGylated peptides can aggregate - do not shake; gentle swirl only.

PEG-MGF Supplier Price Comparison

No tracked suppliers stock PEG-MGF yet — inventory syncs run continuously. Check our supplier reviews.

PEG-MGF FAQ

PEG-MGF is Mechano Growth Factor with a polyethylene glycol chain attached, extending its half-life from minutes to roughly 2-3 days. The active peptide sequence is identical; only stability and clearance change.

No. MGF is the E-domain peptide of the IGF-1Ec splice variant and acts through a different, IGF-1R-independent pathway. It is not interchangeable with IGF-1 or IGF-1 LR3 in research models.

A proper COA should include HPLC purity (98%+) plus mass spectrometry. Because PEG conjugation shifts the observed mass, the COA should state the PEG size used (commonly 2-5 kDa).

Age & Use Verification