PEG-MGF: Research Profile, Dosages & Supplier Prices
PEG-MGF is a growth factor research compound with a molecular weight of ~2948 g/mol (peptide core, excluding PEG) and a research half-life of days (pegylation extends from minutes to ~48-72h). PEG-MGF is the polyethylene glycol-conjugated form of Mechano Growth Factor, the IGF-1Ec splice variant expressed in mechanically loaded or damaged muscle tissue. The 24-amino-acid MGF core is derived from the unique E-domain of IGF-1Ec and is studied for its role in activating muscle satellite cells independently of the IGF-1 receptor pathway used by mature IGF-1.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | PEG-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys |
| Formula | ~C121H200N42O39 + PEG |
| Mol. weight | ~2948 g/mol (peptide core, excluding PEG) |
| Half-life | Days (PEGylation extends from minutes to ~48-72h) |
| Forms sold | Lyophilized powder |
What is PEG-MGF?
Native MGF has an extremely short half-life of only minutes, which limits experimental utility. PEGylation - covalent attachment of a polyethylene glycol chain - shields the peptide from proteolysis and renal clearance, extending its research half-life to several days. Preclinical studies have examined PEG-MGF in models of muscle injury, cardiac repair after ischemia, and neuroprotection. Because PEGylation chemistry varies between suppliers, mass-spec confirmation of the conjugate is a key quality check.
Mechanism of Action (Research Context)
The MGF E-domain peptide acts through an IGF-1R-independent pathway (putatively via a distinct receptor) to promote satellite cell activation and proliferation while suppressing premature differentiation. PEGylation does not change receptor pharmacology but dramatically reduces proteolytic degradation and renal clearance.
Research Areas
PEG-MGF Dosages in Research
Animal studies have used microgram-per-kilogram doses given the extended half-life; far less frequent administration than native MGF. Research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Lyophilized: -20C desiccated and protected from light. Reconstituted: 2-8C, use within 2-3 weeks. PEGylated peptides can aggregate - do not shake; gentle swirl only.
PEG-MGF Supplier Price Comparison
| Supplier | Product | Price | Score |
|---|---|---|---|
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| Research Peptides | PEG-MGF | — | ★ 1.8 |
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