P21: Research Profile, Dosages & Supplier Prices

Neuropeptide research · Lyophilized powder · Also known as: P021, CNTF-derived peptide mimetic

P21 is a neuropeptide research compound with a molecular weight of ~649 g/mol and a research half-life of hours; bbb-penetrant, orally bioavailable in animal models. P21 (P021) is a small peptidomimetic derived from the biologically active region of ciliary neurotrophic factor (CNTF), engineered with an adamantane group for blood-brain barrier penetration and oral bioavailability. It was developed to capture CNTF's neurotrophic and neurogenic activity in a drug-like small molecule.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Adamantane-conjugated tetrapeptide mimetic (derived from CNTF residues 148-153 region)
Formula	C30H47N7O9 (approx)
Mol. weight	~649 g/mol
Half-life	Hours; BBB-penetrant, orally bioavailable in animal models
Forms sold	Lyophilized powder

What is P21?

In preclinical research P21 enhances neurogenesis and synaptic plasticity, reduces tau hyperphosphorylation and amyloid pathology in Alzheimer's mouse models, and improves performance in cognition tasks. It acts partly by inhibiting LIF signaling leakage and modulating BDNF/TrkB and GSK3 pathways. Like Dihexa it is strictly preclinical, and it is one of the more pharmacologically sophisticated 'nootropic peptides' in research catalogs.

Mechanism of Action (Research Context)

CNTF-mimetic: modulates neurotrophic signaling including BDNF/TrkB enhancement and GSK3beta inhibition (reducing tau hyperphosphorylation), promotes dentate gyrus neurogenesis and synaptic plasticity.

Research Areas

Adult neurogenesisAlzheimer's disease models (tau and amyloid)Synaptic plasticityCNTF mimetic pharmacology

P21 Dosages in Research

5mg10mg

Animal studies used oral or intraperitoneal dosing over weeks-to-months in Alzheimer's-model mice. No human data. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated. Reconstituted: 2-8C, use within 2 weeks.

P21 Supplier Price Comparison

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P21 FAQ

It is a peptidomimetic of ciliary neurotrophic factor (CNTF), engineered with an adamantane moiety for blood-brain barrier penetration and oral stability.

Alzheimer's disease models primarily: it enhances hippocampal neurogenesis, reduces tau hyperphosphorylation and amyloid burden, and improves cognition in transgenic mice. Strictly preclinical.

No - completely unrelated. The cell-cycle inhibitor p21 (CDKN1A) is a 21 kDa protein; the research compound P21/P021 is a small CNTF-derived peptidomimetic. The shared name is a coincidence.

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