Noopept: Research Profile, Dosages & Supplier Prices

Neuropeptide research · Powder (oral) · Also known as: N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111, Omberacetam

Noopept is a neuropeptide research compound with a molecular weight of 318.4 g/mol and a research half-life of short (~30-60 min parent; active metabolite cycloprolylglycine persists). Noopept (GVS-111) is a synthetic dipeptide-derived nootropic developed in Russia, structurally based on the endogenous cyclic dipeptide cycloprolylglycine. Though often grouped with racetams, it is pharmacologically distinct and active at far lower doses. It is approved as a cognitive medication in Russia and widely sold elsewhere as a research compound.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Dipeptide-derived: phenylacetyl-Pro-Gly ethyl ester
Formula	C17H22N2O4
Mol. weight	318.4 g/mol
Half-life	Short (~30-60 min parent; active metabolite cycloprolylglycine persists)
Forms sold	Powder (oral)

What is Noopept?

Preclinical research shows neuroprotective, anxiolytic and cognition-enhancing effects, with proposed mechanisms including increased BDNF/NGF expression, cholinergic modulation, AMPA-receptor effects and antioxidant activity. Its active metabolite cycloprolylglycine is itself an endogenous peptide with anti-amnesic properties. Noopept has a modest human trial literature from Russia alongside a much larger animal literature.

Mechanism of Action (Research Context)

Prodrug-like behavior: rapidly metabolized to cycloprolylglycine. Increases hippocampal BDNF and NGF expression, modulates cholinergic and glutamatergic (AMPA) transmission, and shows antioxidant and anti-inflammatory effects in neural tissue.

Research Areas

Cognitive enhancement modelsNeuroprotectionBDNF/NGF expressionAnxiety models

Noopept Dosages in Research

10mg30mg (research reference)

Russian clinical use was 10-30 mg/day orally. Active at milligram doses unlike gram-dose racetams. Research-context only outside approved markets.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Powder: room temperature or 2-8C, desiccated, protected from light. Stable for a peptide-derived compound.

Noopept Supplier Price Comparison

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Noopept FAQ

It is a dipeptide-derived molecule (phenylacetyl-prolylglycine ethyl ester) - technically a peptide derivative, which is why it appears in peptide research catalogs alongside true peptides.

Noopept is active at milligram doses (piracetam requires grams), has a different structure, and works partly through BDNF/NGF upregulation and its cycloprolylglycine metabolite rather than the racetam mechanism.

98%+ HPLC purity with identity confirmed at 318.4 Da. As a cheap small molecule, underdosing is less common than with expensive peptides, but identity testing still matters.

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