Mod GRF 1-29: Research Profile, Dosages & Supplier Prices

Growth hormone secretagogue · Lyophilized powder · Also known as: CJC-1295 no DAC, Modified GRF (1-29), tetrasubstituted GRF 1-29

Mod GRF 1-29 is a growth hormone secretagogue compound with a molecular weight of 3367.9 g/mol and a research half-life of ~30 minutes. Mod GRF 1-29 is a tetrasubstituted analog of the shortest fully functional fragment of growth hormone-releasing hormone (GHRH 1-29). Four amino-acid substitutions (including D-Ala at position 2) protect it from rapid DPP-IV enzymatic cleavage, extending its half-life from under 10 minutes to roughly 30 minutes while preserving full GHRH receptor potency.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Formula	C152H252N44O42
Mol. weight	3367.9 g/mol
Half-life	~30 minutes
Forms sold	Lyophilized powder

What is Mod GRF 1-29?

It is the base peptide of CJC-1295: CJC-1295 is simply Mod GRF 1-29 conjugated to a Drug Affinity Complex (DAC) that binds albumin and stretches the half-life to about a week. In research, Mod GRF 1-29 is preferred when a pulsatile, physiologic GH release pattern is desired, and it is one of the most common partners for GHRP-class compounds (ipamorelin, GHRP-2, GHRP-6) in synergy studies, since GHRH and ghrelin-receptor pathways amplify each other.

Mechanism of Action (Research Context)

Agonist at the pituitary GHRH receptor (GHRHR), stimulating adenylyl cyclase and cAMP-mediated growth hormone synthesis and pulsatile release from somatotroph cells. The D-Ala2 substitution confers DPP-IV resistance; Gln8, Ala15 and Leu27 substitutions further stabilize the peptide.

Research Areas

Growth hormone axis regulationGHRH receptor pharmacologyPituitary somatotroph signalingGHRH/GHRP synergy models

Mod GRF 1-29 Dosages in Research

2mg5mg vials

Research protocols typically pair GHRH-class peptides with a GHRP to exploit pathway synergy. Short half-life means pulsatile timing matters in study design. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated. Reconstituted: 2-8C, use within 2-3 weeks. Avoid vigorous shaking; swirl gently to dissolve.

Mod GRF 1-29 Supplier Price Comparison

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Mod GRF 1-29 FAQ

Mod GRF 1-29 is CJC-1295 without the Drug Affinity Complex (DAC). The DAC conjugation extends half-life from ~30 minutes to ~6-8 days. Many products sold as 'CJC-1295 no DAC' are exactly Mod GRF 1-29.

GHRH-receptor and ghrelin-receptor (GHS-R) activation are synergistic: co-administration produces a larger GH pulse than either alone in published studies, making the pair a standard secretagogue research model.

98%+ HPLC purity and mass spec identity at 3367.9 Da. Because the name is often confused with CJC-1295 DAC, check the COA lists the correct molecular weight.

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