MK-677: Research Profile, Dosages & Supplier Prices

Growth hormone secretagogue (small molecule) · Powder / solution (oral) · Also known as: Ibutamoren, Nutrobal, MK-0677

MK-677 is a growth hormone secretagogue (small molecule) compound with a molecular weight of 528.7 g/mol and a research half-life of ~24 hours (gh/igf-1 elevation); plasma ~4-6 hours. MK-677 (ibutamoren) is an orally active, non-peptide agonist of the ghrelin receptor (GHS-R1a) - the same receptor the GHRP peptides target. It was developed by Merck as an oral growth hormone secretagogue and remains the most studied compound in its class, with multiple human trials showing sustained increases in GH and IGF-1 levels.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Non-peptide small molecule (ghrelin receptor agonist)
Formula	C27H36N4O5S
Mol. weight	528.7 g/mol
Half-life	~24 hours (GH/IGF-1 elevation); plasma ~4-6 hours
Forms sold	Powder / solution (oral)

What is MK-677?

Unlike injectable GHRPs, MK-677 is orally bioavailable with a once-daily profile, elevating GH pulsatility and IGF-1 for 24 hours. Human studies have examined muscle wasting, bone density, sleep architecture (it increases REM and deep sleep duration) and growth hormone deficiency. Increased appetite - the ghrelin signature - is its most consistent effect. It is the reference oral secretagogue against which the injectable peptide class is compared.

Mechanism of Action (Research Context)

Agonist at the ghrelin/growth hormone secretagogue receptor (GHS-R1a) in pituitary and hypothalamus, amplifying pulsatile GH release and downstream hepatic IGF-1 production. Oral bioavailability and long functional duration distinguish it from peptide GHRPs.

Research Areas

GH/IGF-1 axis stimulationMuscle wasting and anabolism researchSleep architecture (REM/deep sleep)Bone density modelsGhrelin receptor pharmacology

MK-677 Dosages in Research

10mg25mg (trial reference doses)

Human trials used 10-50 mg once daily orally, with 25 mg the most studied dose. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Powder: room temperature desiccated. In solution: 2-8C. Stable small molecule with good shelf life.

MK-677 Supplier Price Comparison

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MK-677 FAQ

No - it is an orally active small molecule targeting the ghrelin receptor, the same receptor as GHRP peptides. It is grouped with secretagogues because it raises GH and IGF-1 through the identical pathway.

Same receptor (GHS-R1a), same downstream GH/IGF-1 elevation, but MK-677 is oral and once-daily with 24-hour coverage, while injectable GHRPs are short-acting pulses. MK-677 also has far more human trial data.

98%+ HPLC purity and mass spec identity at 528.7 Da. It is one of the most counterfeited research compounds - third-party identity testing is essential.

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