Melanotan II: Research Profile, Dosages & Supplier Prices

Melanocortin research · Lyophilized vial, nasal spray · Also known as: MT-2, MT-II, Melanotan 2

Melanotan II is a melanocortin research compound with a molecular weight of 1024.2 g/mol and a research half-life of short plasma half-life; receptor effects persist longer in research models. Melanotan II is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH) developed originally at the University of Arizona for skin cancer prevention research. It is a non-selective melanocortin receptor agonist (MC1R through MC5R).

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Formula	C50H69N15O9
Mol. weight	1024.2 g/mol
Half-life	Short plasma half-life; receptor effects persist longer in research models
Forms sold	Lyophilized vial, nasal spray

What is Melanotan II?

Published research has examined MT-II in pigmentation studies (MC1R), appetite and energy homeostasis models (MC3R/MC4R), and sexual function research (MC4R). Its melanocortin receptor promiscuity explains the breadth of its published research literature.

MT-II is one of the oldest and most saturated products in the research peptide market. Quality concerns center on purity (the cyclization step is failure-prone) - look for HPLC chromatograms showing a single dominant peak.

Mechanism of Action (Research Context)

Non-selective agonist at melanocortin receptors MC1R-MC5R, stimulating melanogenesis (MC1R) and influencing appetite and autonomic pathways (MC3R/MC4R) in research models.

Research Areas

Melanogenesis researchMelanocortin receptor pharmacologyAppetite regulation modelsUV-protection research

Melanotan II Dosages in Research

10mg

Published human pilot research used very low microgram-per-kilogram doses. Research vials are almost universally 10mg. Laboratory research use only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C, protect from light. Reconstituted: 2-8C, use within 30 days.

Melanotan II Supplier Price Comparison

Supplier	Product	Price	Score
Buy Peptides	Melanotan II Spray	$49.99	★ 2.3
Certified Pep	MELANOTAN -MT2- 10MG 10mg	$50.00	★ 9.8

Melanotan II FAQ

Melanotan I (afamelanotide) is a linear peptide with more selective MC1R activity and is an approved drug for erythropoietic protoporphyria. Melanotan II is a cyclic, non-selective melanocortin agonist sold only as a research compound.

The head-to-tail cyclization step in synthesis is chemically failure-prone, producing deletion and linear byproducts. Quality vendors show clean single-peak HPLC chromatograms per batch.

Age & Use Verification