Matrixyl: Research Profile, Dosages & Supplier Prices

Cosmetic / tissue research · Lyophilized powder · Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS, Matrixyl 3000 component

Matrixyl is a cosmetic / tissue research compound with a molecular weight of 802.1 g/mol and a research half-life of topical/local research use; palmitoyl tail improves skin retention. Matrixyl (palmitoyl pentapeptide-4) is a lipopeptide built from the KTTKS sequence - a matrikine fragment of collagen type I - conjugated to a palmitic acid tail that improves skin penetration and retention. Matrikines are natural collagen breakdown fragments that signal fibroblasts to begin repair; Matrixyl packages that signal in a delivery-optimized form.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH
Formula	C39H75N7O10
Mol. weight	802.1 g/mol
Half-life	Topical/local research use; palmitoyl tail improves skin retention
Forms sold	Lyophilized powder

What is Matrixyl?

It is among the most clinically studied cosmetic peptides: double-blind trials report increased collagen and fibronectin synthesis and measurable wrinkle reduction with topical use. In research it serves as the reference matrikine peptide for studying fibroblast activation, extracellular matrix synthesis, and lipid-conjugation delivery strategies. The popular 'Matrixyl 3000' formulation pairs it with palmitoyl tetrapeptide-7.

Mechanism of Action (Research Context)

Matrikine signaling: the KTTKS motif (from collagen I alpha chains) activates fibroblasts, upregulating collagen I/III, fibronectin and elastin synthesis. The palmitoyl tail enhances stratum corneum penetration and peptide stability.

Research Areas

Fibroblast activation and ECM synthesisMatrikine signalingWrinkle / photoaging modelsLipopeptide delivery strategies

Matrixyl Dosages in Research

100mg1g (cosmetic formulation research)

Cosmetic research formulations typically use 2-8% solutions. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated. In solution: 2-8C, use within weeks. The lipid tail reduces water solubility - follow formulation guidance for solubilization.

Matrixyl Supplier Price Comparison

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Matrixyl FAQ

The KTTKS pentapeptide - a natural matrikine fragment of collagen type I - linked to palmitic acid. The lipid tail improves skin penetration and stability.

Collagen, fibronectin and elastin synthesis in skin models, photoaging and wrinkle research. It has some of the strongest cosmetic clinical data of any peptide.

Matrixyl is palmitoyl pentapeptide-4 (Pal-KTTKS). Matrixyl 3000 is a formulation combining it with palmitoyl tetrapeptide-7 (Pal-GQPR), a complementary anti-inflammatory matrikine.

Age & Use Verification