LL-37: Research Profile, Dosages & Supplier Prices

Immune research · Lyophilized powder · Also known as: hCAP-18 fragment, Cathelicidin LL-37

LL-37 is a immune research compound with a molecular weight of 4493.3 g/mol and a research half-life of short (rapid proteolytic turnover). LL-37 is the only human member of the cathelicidin family of antimicrobial peptides - a 37-amino-acid alpha-helical peptide cleaved from the hCAP-18 precursor protein. It is produced by neutrophils, epithelial cells and keratinocytes and serves as a first-line innate immune effector with direct broad-spectrum antimicrobial activity against bacteria, fungi and enveloped viruses.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Formula	C205H340N60O53
Mol. weight	4493.3 g/mol
Half-life	Short (rapid proteolytic turnover)
Forms sold	Lyophilized powder

What is LL-37?

Beyond direct pathogen killing, LL-37 is heavily studied as an immune modulator: it chemoattracts immune cells, neutralizes bacterial endotoxin (LPS), modulates TLR signaling, and influences wound healing and angiogenesis. Research spans infection models, biofilm disruption, inflammatory bowel disease, psoriasis (where LL-37 is implicated as an autoantigen), and even cancer biology. Its dual pro- and anti-inflammatory behavior makes it one of the more context-dependent peptides in the research catalog.

Mechanism of Action (Research Context)

Amphipathic alpha-helix inserts into and disrupts microbial membranes (carpet/toroidal-pore models). Binds and neutralizes LPS. Immunomodulatory actions via FPRL-1/FPR2, P2X7 and EGFR transactivation; chemotactic for neutrophils, monocytes and T cells.

Research Areas

Antimicrobial and antibiofilm activityInnate immune modulationEndotoxin (LPS) neutralizationWound healing and re-epithelializationPsoriasis and autoimmune skin models

LL-37 Dosages in Research

5mg10mg vials

Cell-culture antimicrobial assays typically use low micromolar concentrations; animal infection models use microgram-per-kilogram dosing. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated. Reconstituted: 2-8C, use within 1-2 weeks. LL-37 aggregates readily in solution - prepare fresh dilutions and avoid repeated freeze-thaw.

LL-37 Supplier Price Comparison

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LL-37 FAQ

Primarily innate immunity: direct antimicrobial and antibiofilm activity, LPS neutralization, immune cell recruitment, and wound repair. It is also studied in psoriasis and IBD because of its role in inflammatory signaling.

Both, depending on context - it neutralizes endotoxin and can dampen TLR responses, yet acts as an alarmin and autoantigen in psoriasis models. This context-dependence is a major research theme.

98%+ HPLC purity and mass spec identity at 4493.3 Da. Aggregation in solution is normal for this peptide and does not itself indicate impurity.

Age & Use Verification