IGF-DES: Research Profile, Dosages & Supplier Prices
IGF-DES is a growth factor research compound with a molecular weight of 7371.4 g/mol and a research half-life of ~20-30 minutes. IGF-DES (Des(1-3)IGF-1) is a truncated analog of human IGF-1 missing the first three N-terminal amino acids. This small structural change has a large pharmacological effect: IGF-DES binds IGF-binding proteins (IGFBPs) roughly 100-fold less avidly than native IGF-1, leaving far more free, receptor-available peptide in tissue.
Research Use Only (RUO). Not for human or veterinary use. Not medical advice.
| Sequence | 67-aa truncated IGF-1 lacking the N-terminal Gly-Pro-Glu tripeptide |
| Formula | C319H501N91O96S7 |
| Mol. weight | 7371.4 g/mol |
| Half-life | ~20-30 minutes |
| Forms sold | Lyophilized powder |
What is IGF-DES?
The result is a short-acting but highly potent research tool - reported as several-fold more potent than IGF-1 at the IGF-1 receptor in-vitro, with a plasma half-life of only 20-30 minutes. Research interest centers on localized tissue growth models, muscle repair, and neuronal studies. It sits between native IGF-1 and the long-acting IGF-1 LR3 in the potency/duration trade-off, and its short half-life makes timing and localization central to study design.
Mechanism of Action (Research Context)
Agonist at the IGF-1 receptor (IGF-1R), activating PI3K/Akt and Ras/MAPK pathways driving cell proliferation, protein synthesis and glucose uptake. N-terminal truncation reduces IGFBP binding ~100x, increasing free bioactive fraction; potency at the receptor itself is enhanced relative to native IGF-1.
Research Areas
IGF-DES Dosages in Research
Microgram-range research compound with very short half-life; studied for localized rather than systemic effects. Research-context only.
Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.
Storage & Handling
Lyophilized: -20C desiccated. Reconstituted: 2-8C in acetic acid or bacteriostatic water per protocol; use within 1-2 weeks. Avoid freeze-thaw.
IGF-DES Supplier Price Comparison
| Supplier | Product | Price | Score |
|---|---|---|---|
| Amino Asylum Official Site | IGF-DES 1mg | Amino Asylum Research Peptide 1mg | $49.99 | ★ 2.2 |
| Australian Peptides Store | IGF-DES 2mg × 10 vials 2mg | $50.00 | ★ 2.4 |
| Home | IGF-DES 0.1mg Kit 0.1mg | $56.00 | ★ 2.0 |
| Research Peptides — Third | IGF-DES (0.1mg) 0.1mg | $69.99 | ★ 1.9 |
| Home | IGF-DES 100MCG 100MCG | $74.99 | ★ 1.9 |
| American Select Peptides – Research peptides and analytical standards for qualified laboratories. | IGF-DES | $79.00 | ★ 1.7 |
| Buy Peptides for Laboratory Research | IGF-DES 2mg 2mg | $184.99 | ★ 2.8 |