Humanin: Research Profile, Dosages & Supplier Prices

Mitochondrial research · Lyophilized powder · Also known as: HN, MT-RNR2 peptide

Humanin is a mitochondrial research compound with a molecular weight of 2687.2 g/mol and a research half-life of hours. Humanin is a 24-amino-acid peptide encoded within the mitochondrial 16S rRNA gene (MT-RNR2) - one of the first discovered 'mitochondrial-derived peptides', a class of small signaling molecules encoded by short open reading frames in mitochondrial DNA. It was identified in 2001 from a screen for factors protecting neurons against Alzheimer's-related insults.

Research Use Only (RUO). Not for human or veterinary use. Not medical advice.

Sequence	Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Formula	C118H204N34O31S2
Mol. weight	2687.2 g/mol
Half-life	Hours
Forms sold	Lyophilized powder

What is Humanin?

Research has since shown humanin acts as a broad cytoprotective and metabolic signaling peptide: circulating levels decline with age, and higher levels correlate with longevity in several species including humans. Studied areas include neuroprotection, insulin sensitivity and glucose metabolism, cardiovascular protection, and apoptosis regulation. Potent analogs such as HNG (S14G-humanin) are used in research where greater potency is needed. Humanin signals through both intracellular (BAX-binding) and cell-surface receptor (CNTFR/WSX-1/gp130 and FPRL-1) pathways.

Mechanism of Action (Research Context)

Dual signaling: extracellular humanin activates a tripartite receptor complex (CNTFRalpha/WSX-1/gp130) triggering JAK2/STAT3 and AKT survival pathways, and binds FPRL-1/FPR2. Intracellular humanin binds pro-apoptotic BAX and IGFBP3, suppressing mitochondria-mediated apoptosis.

Research Areas

Neuroprotection and Alzheimer's modelsInsulin sensitivity and metabolic regulationCardiovascular protectionApoptosis regulationAging and longevity research

Humanin Dosages in Research

5mg10mg vials

Animal metabolic and neuroprotection studies typically use low milligram-per-kilogram dosing; the S14G analog (HNG) is roughly 1000x more potent in some assays. Research-context only.

Dosage information is a summary of published laboratory research and is provided for informational purposes only. These compounds are not for human use.

Storage & Handling

Lyophilized: -20C desiccated. Reconstituted: 2-8C, use within 2-3 weeks. Contains methionine and cysteine - oxidation-sensitive; minimize air exposure of solutions.

Humanin Supplier Price Comparison

No tracked suppliers stock Humanin yet — inventory syncs run continuously. Check our supplier reviews.

Humanin FAQ

Peptides encoded by small open reading frames within mitochondrial DNA rather than nuclear DNA. Humanin was the first discovered; MOTS-c is another. They act as retrograde signals from mitochondria to the rest of the cell and body.

Neuroprotection (originally Alzheimer's models), insulin sensitization and metabolic health, cardiovascular protection, and aging research - circulating humanin declines with age and correlates with longevity.

HNG is the S14G analog of humanin - a single serine-to-glycine substitution at position 14 that increases potency roughly 1000-fold in neuroprotection assays. It is a distinct research reagent from native humanin.

Age & Use Verification